A model for educational simulation of drug dependent intrauterine pressure signals during labor and delivery

Tese de mestrado. Engenharia Biomédica. Faculdade de Engenharia. Universidade do Porto, Instituto Nacional de Engenharia Biomédica. 200

Accuracy of models of confined concrete in rectangular columns using different proposals for the prediction of failure of the FRP

Confinement with externally applied fiber reinforced polymers (FRP), such as carbon, glass and aramid-based composites, results in notorious improvement of ductility and strength. Several constitutive models, regarding stress–strain relationship, have been proposed. However, few models exist for square and rectangular columns confined with FRP when compared with the number of models for circular concrete columns, and even fewer models satisfactorily predict the failure strain of FRP. In this paper, the accuracy of existing models for the prediction of the failure strain of the FRP is evaluated. Comparison of analytical results with experimental test results of concrete columns reported in the literature is presented, focusing different parameters such as strength, maximum strain and strain energy density.info:eu-repo/semantics/publishedVersio

Accuracy of models of concrete in circular columns using different proposals for the prediction of failure of the confining FRP

Confinement of concrete columns with fiber reinforced polymers results in an increase of strength and ductility. For this reason, the use of aramid, carbon and glass-based composites for confinement of reinforced concrete columns has significantly increased over the last decades. Nevertheless, few models adequately predict the failure strain of the fiber reinforced polymer, which has a determinant influence on the computed results. In this paper the accuracy of existing models of confined concrete using different proposals for the prediction of the failure strain of the confining composite is assessed. This is based on the comparison of analytical results with experimental test results of concrete columns with circular cross-section reported in the literature. The comparison focusses on different parameters such as strength, maximum strain and strain energy density.info:eu-repo/semantics/publishedVersio

MIGUEL ANGEL GARRIDO. Crítica Literaria (La doctrina de Lucien Goldmann). Madrid, RIALP, 1996; 235 pp.

No contiene resume

Novos alvos terapêuticos no tratamento da doença de Parkinson

Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2020, Universidade de Lisboa, Faculdade de Farmácia.A doença de Parkinson é a segunda doença neurodegenerativa mais comum no mundo. Caracteriza-se pela perda de função progressiva dos neurónios dopaminérgicos na porção compacta da substância negra e pela acumulação de inclusões proteicas denominadas corpos de Lewy e neurites de Lewy. Clinicamente, a doença caracteriza-se por quatro sintomas motores: bradicinesia, rigidez, tremor em repouso e instabilidade postural, associados a uma variedade de sintomas não motores que podem afetar vários sistemas orgânicos, podendo ir desde transtornos de humor até problemas de pele, como a dermatite seborreica e a hiperidrose. As opções terapêuticas atualmente disponíveis incluem tratamento farmacológico, intervenções cirúrgicas, como a estimulação cerebral profunda, palidotomias e talamotomias ou terapêuticas não farmacológicas, como a fisioterapia. O controlo farmacológico dos sintomas motores é feito através da administração de quatro grupos de fármacos principais: levodopa ou agonistas da dopamina, inibidores da monoamina oxidase e da catecol O-metiltransferase, antagonistas não seletivos dos recetores muscarínicos de acetilcolina e antagonistas do recetor N-metil D-aspartato ativado pelo glutamato. No entanto, todas estas opções fornecem tratamento direcionado ao controlo sintomático nos primeiros anos após o diagnóstico, tornando-se menos eficazes à medida que a doença avança. Não existem atualmente terapêuticas disponíveis que previnam o início ou abrandem a progressão da doença de Parkinson. Esta monografia foca-se em potenciais novos alvos terapêuticos, nomeadamente a α-sinucleína, a LRRK2, a PINK1 e a parkin, que, por terem um papel chave na sua fisiopatologia, oferecem a perspetiva do desenvolvimento de novos medicamentos que possam modificar o avanço natural da doença. Estas proteínas têm sido associadas tanto à doença de Parkinson genética quanto à sua forma não genética. Serão abordadas neste trabalho as várias estratégias terapêuticas, atualmente em estudo, que têm como alvo alguma destas quatro proteínas, incluindo alguns compostos já em fase de ensaios clínicos.Parkinson's disease is the second most common neurodegenerative disease in the world. It is characterized by the progressive loss of dopaminergic neurons function in the substantia nigra pars compacta and by the accumulation of protein inclusions called Lewy’s bodies and Lewy’s neurites. Clinically, the disease is characterized by four motor symptoms: bradykinesia, stiffness, tremor at rest and postural instability, associated with a variety of non-motor symptoms that can affect various organ systems, ranging from mood disorders to skin problems, such as seborrheic dermatitis and hyperhidrosis. The current available therapeutic options include pharmacological treatment, surgical interventions, such as deep brain stimulation, pallidotomies and thalamotomies, or non-pharmacological therapies, such as physiotherapy. The pharmacological management of motor symptoms is done through the administration of four main groups of drugs: levodopa or dopamine agonists, monoamine oxidase and catechol-O-methyltransferase inhibitors, non-selective muscarinic acetylcholine receptor antagonists and N-methyl-D-aspartate receptor of glutamate antagonists. However, all of these options provide treatment only for symptomatic control and are only effective in the first few years after diagnosis, becoming less effective as the disease progresses. There are currently no therapies available to prevent the onset or slow the progression of Parkinson's disease. This monography focuses on potential new therapeutic targets, namely α-synuclein, LRRK2, PINK1 and parkin, which, by playing a key role in their pathophysiology, offer the prospect of developing new drugs that can modify the natural course of the disease. These proteins have been associated with both familial and sporadic forms of Parkinson's disease. This monography addresses the various therapeutic strategies currently under study that target any of these four proteins, and include some compounds already in clinical trials

A relevância atribuída pelos/as educadores/as de infância às áreas de conteúdo: implicações da Teoria das Inteligências Múltiplas em contexto de pré-escolar

Relatório final apresentado para a obtenção do grau de Mestre na especialidade de Educação Pré-EscolarO presente relatório, realizado no âmbito do Mestrado em Educação Pré-Escolar, divide-se em dois grandes capítulos: o primeiro destes é uma reflexão às três práticas pedagógicas realizadas durante o mestrado, apresentando os projetos implementados, algumas das suas atividades e o processo de desenvolvimento pessoal. O segundo capítulo concerne à dimensão investigativa, orientada por duas questões: “Pode-se estabelecer uma relação entre as áreas de conteúdo das Orientações Curriculares para o Pré-Escolar (OCEPE) e as inteligências múltiplas de Howard Gardner?” e “Como são trabalhadas as áreas de conteúdo pelos educadores de infância no pré-escolar?”. No decorrer desta pesquisa foi utilizada a metodologia quantitativa, recorrendo-se a inquéritos por questionário aplicados a uma amostra de 107 educadores/as de infância. As principais conclusões da pesquisa indicam que existe uma relação, mesmo que indireta, entre as áreas de conteúdo das OCEPE e a teoria de Gardner. Aproximadamente metade dos educadores de infância atribuem a mesma relevância a todas as áreas de conteúdo, enquanto que os restante mostraram ter prevalência por duas das áreas de conteúdo.This document, made in the scope of a dissertation in Pre-school education, it's divided in two big chapters: the first reflects three pedagogical practices used during the dissertation, presenting the projects that were in use, some of their activities and the process of personal development. The second chapter is about the investigation's dimension guided by two questions: "Can you established a connection between the areas of Pre-School Curriculum Guidelines and the multiple intelligences of Howard Gardner?" and "How are the areas of contents work by teachers in preschool?" During this research the quantitative methodology was used recurring to surveys to a sample of 107 preschool teachers. The main conclusions of the research indicate that there is a relationship, although indirectly, between the areas of Pre-School Curriculum Guidelines and Gardner's theory. Approximately half of all preschool teachers attribute the same relevance to all areas, while the rest showed to be prevalent to two of these areas.N/

Pengaruh Penggunaan Obat Nyamuk, Karakteristik Balita Dan Perilaku Keluarga Terhadap Kejadian Infeksi Saluran Pernapasan Akut (Ispa) Pada Balita

   Infeksi Saluran Pernapasan Akut adalah penyakit infeksi yang menyerang salah satu bagian atau lebih dari saluran pernapasan. Penelitian ini bertujuan untuk mencari faktor-faktor dan faktor yang dominan mempengaruhi kejadian Infeksi Saluran Pernapasan Akut pada balita di Puskesmas Nulle, Kabupaten Timor Tengah Selatan. Data yang digunakan dalam penelitian ini yaitu jumlah balita penderita Infeksi Saluran Pernapasan Akut, jenis kelamin balita, berat badan lahir, ASI eksklusif, status imunisasai, status gizi, umur ibu, pendidikan ibu, pendapatan keluarga, keluarga merokok, penggunaan obat nyamuk dan bahan bakar memasak. Dalam penelitian ini, digunakan metode Analisis Faktor untuk menganalisis dalam hal ini mereduksi dua belas (12) variabel penelitian sehingga diperoleh tiga (3) faktor baru yang disebut faktor penggunaan obat nyamuk dan polusi udara, faktor karakteristik balita serta faktor keluarga merokok dengan variansnya berturut-turut adalah: 30,681%, 19,805% dan 13,510% dengan nilai eigennya 2,454, 1,584 dan 1,081. Sehingga diperoleh faktor yang dominan mempengaruhi kejadian Infeksi Saluran Pernapasan Akut  pada balita adalah faktor penggunaan obat nyamuk dan polusi udara yaitu dengan varians sebesar 30,681% dan nilai eigen sebesar 2,454